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. 2022 Oct 7;13:1027731. doi: 10.3389/fphar.2022.1027731

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Copyright © 2022 Zhong, Chen, Pan, Tang, Zhong, Guo, Cui, Li, Duan, Yang, Gao, Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ginsenoside Rc suppressed APAP-induced hepatocellular damage by reducing oxidative stress, and inflammation in MPHs. (A) CCK8 assay; (B) Ginsenoside Rc treatment inhibits the expression of Bcl2 protein and restrains the expression of bax in MPHs. (C) The TUNEL assay was performed to measure the apoptosis effect in MPHs. (D) Relative expression of mRNA associated with antiapoptosis (P53, Caspase, Bcl2/Bax);(E) Relative expression of mRNA associated with oxidative stress (Sod2,Gclc, Gclm); (F) Relative expressions of mRNA associated with inflammation (Il-6, Il-1β, TNF-α); (G) The ELISA assay showed that Ginsenoside Rc treatment decreased NAPQI levels in MPHs; (H) Relative expression of RNA associated with APAP-metabolizing enzymes (Cyp3a11,Cyp2E,Ugt1a11); Data are means ± SEM; n = 3-6/group.*, p < 0.05, **, p < 0.01, ***, p < 0.001.