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. 2022 Oct 7;13:1027731. doi: 10.3389/fphar.2022.1027731

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Copyright © 2022 Zhong, Chen, Pan, Tang, Zhong, Guo, Cui, Li, Duan, Yang, Gao, Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ginsenoside Rc alleviated hepatic damage in ALI mice by regulating oxidative stress. (A) The survival rate of mice (with/without Ginsenoside Rc treatment) after intraperitoneal injection of APAP for 72 h(B) The ratio of liver weight/body weight; (C) Serum ALT and AST levels; (D) H&E staining of livers (1000×); (E) Hepatic GSH and SOD levels were reduced in APAP-induced mice after Ginsenoside Rc treatment; (F) Expression of mRNA levels of oxidative stress genes (Sod2, Gclc, Gclm); (G) Hepatic ROS levels were decreased in APAP-induced mice after Ginsenoside Rc treatment; (H) Relative expression of mRNA associated with APAP-metabolizing enzymes (Cyp3a11, Cyp2E, Ugt1a11); (I) The ELISA assay showed Ginsenoside Rc treatment decreased NAPQI levels in APAP-administrated mice. Data are means ± SEM; n = 5-8/group. *,p < 0.05, **; p < 0.01, ***; p < 0.001.