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. 2022 Oct 7;13:990571. doi: 10.3389/fimmu.2022.990571

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Copyright © 2022 Yuan, Liu, Wu, Yan, Yang and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The culture of HCC sorafenib-resistant cell lines. (A) Schematic overview of the workflow in this study. (B) CCK-8 assays for parental HCC cells and corresponding sorafenib-resistant HCC cells treated with a range of concentrations of sorafenib. Cell viability was assessed 3 d after sorafenib treatment. (C) Clonogenic cell survival assay in specified cells treated with sorafenib for 24 h. (D) CCK-8 assays for parental HCC cells and corresponding sorafenib-resistant HCC cells treated with a range of concentrations of lenvatinib. Cell viability was assessed 5 d after lenvatinib treatment. (E) Clonogenic cell survival assay in specified cells treated with 10 μmol lenvatinib for 24 h. The asterisks in B and D represent the statistical p-value (**P< 0.01).