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. 2022 Oct 7;13:990571. doi: 10.3389/fimmu.2022.990571

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Copyright © 2022 Yuan, Liu, Wu, Yan, Yang and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of a nomogram predicting OS outcomes based on the MDH risk score in the TCGA-LIHC cohort. (A) Coefficients of 4 genes involved in the prognostic signatures. (B) Representative IHC images of ATAD3A, CHAF1B and ADH4 in MDH high- or low-score groups from the Human Protein Atlas. Scale bar denotes 50 μm. (C) Nomogram to predict the 3‐y and 5‐y overall survival of HCC patients. (D) Calibration curve for the comprehensive survival nomogram model in the TCGA-LIHC cohort. The dashed diagonal line represents the ideal situation, and the blue and red lines represent the 3‐y and 5‐y observed nomograms, respectively. (E) Survival analysis for the MDH risk score in the ICGC cohort. (F) Alluvial diagram showing the association of the MDH subtype with patient survival status, MDH score and individualized therapy.