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. 2022 Oct 7;13:1017331. doi: 10.3389/fendo.2022.1017331

Table 6.

Characteristics of Cushing’s disease patients who developed hypokalemia during ketoconazole treatment.

ID Dose (mg) HK episodes K value Disease control BP control Previous medications in use
9 1,200 7 3.3
3.3
3
2.8
2.8
2.8
3
No
No
No
No
Partial
No
No
High
High
Normal
Normal
Normal
High
Normal
HCTZ (suspension) enalapril, spironolactone, PPL, amlodipine, cabergoline, mitotane
15 600 1 3.2 Yes Normal HCTZ
16 1,000 1 2.8 Yes High Spironolactone, furosemide, enalapril, chlorthalidone, simvastatin
8 600 1 3.4 Yes Normal HCTZ
10 800 1 3.1 No High HCTZ
14 800 1 3.3 No Normal HCTZ and captopril
19 1,200 1 2.9 No Unavailable Amlodipine, atenolol, losartan, hydralazine, spironolactone
25 400 1 3.2 Partial High HCTZ
28 1,200 3 2.9
2.6
3.3
Partial
Partial
No
High
High
High
Losartan, chlorthalidone, spironolactone, hydralazine
27 400
400
600
3 3.1
3.4
3.4
Yes
No
Yes
Normal
Normal
Normal
Enalapril and HCTZ

HK, hypokalemia; HCTZ, hydrochlorothiazide; PPL, propranolol.