TABLE 2.

Comparison of promastigote recovery in in vitro culture and parasite burdens in spleens of mice after s.c. priming with graded doses of live UR6 before infection with L. donovani AG83

Group	Priming with live UR6		Infection with AG83 on day 0	Splenic parasite burden (mean ± SD)	% Reduction in splenic parasite burden on day 83 with respect to group A	No. of parasites transformed in vitro culture (mean ± SD)	% Reduction in transformed promastigotes with respect to group A in in vitro culture
	Day 30	Day 15
A			+	(1.5 ± 0.2) × 107		(4.8 ± 0.12) × 107
B	107	107	+	(9.6 ± 0.21) × 106	36.0a	(3.1 ± 0.1) × 107	35.41c
C	108	108	+	(4.86 ± 0.09) × 106	67.6b	(1.0 ± 0.09) × 107	79.16c
D	109	109	+	(6.8 ± 0.08) × 105	95.4c	(3.5 ± 0.04) × 106	92.70c
E	109	109	−		NDd		ND

^aP < 0.01. 

^bP < 0.005. 

^cP < 0.0005. 

^dND, parasite not detected.