TABLE 3.
Parasite burdens in spleens and livers of BALB/c mice after priming with various forms of UR6 before infection with L. donovani AG83a
Group | Priming with 109 UR6 organisms prior to infection with AG83 | Parasite count (mean ± SD) in:
|
% Reduction in parasite burden with respect to group A in:
|
||
---|---|---|---|---|---|
Spleen | Liver | Spleen | Liver | ||
A | (2.70 ± 0.966) × 107 | (5.13 ± 0.66) × 107 | |||
B | Live UR6 | (2.58 ± 1.06) × 105 | (6.00 ± 2.70) × 106 | 99.04b | 88.30e |
C | Heat-killed UR6 | (4.80 ± 2.30) × 105 | (1.33 ± 0.834) × 107 | 98.22b | 74.03d |
D | Formaldehyde-fixed UR6 | (2.28 ± 0.98) × 106 | (3.20 ± 1.14) × 106 | 91.55c | 93.76e |
E | Sonicated UR6 | (1.35 ± 0.35) × 105 | (1.35 ± 0.77) × 105 | 99.50b | 93.68e |
All groups received AG83 on day 0, and splenic and liver parasite burdens were counted on day 90. Mice were primed with UR6 in days 60, 45, and 30 before infection.
P < 0.01.
P < 0.025.
P < 0.005.
P < 0.0005.