TABLE 4.
Parasite burdens in spleens and livers of BALB/c mice after priming through various routes before infection with L. donovani AG83a
Group | Route used for priming | Parasite count (mean ± SD) in:
|
% Reduction in parasite burden with respect to group A in:
|
||
---|---|---|---|---|---|
Spleen | Liver | Spleen | Liver | ||
A | (1.30 ± 0.22) × 108 | (2.87 ± 0.69) × 108 | |||
B | i.v. | (1.44 ± 0.95) × 108 | (6.27 ± 3.25) × 108 | 0b | 0c |
C | i.p. | (4.85 ± 0.55) × 107 | (1.28 ± 0.19) × 107 | 62.69d | 95.50d |
D | s.c. | (2.53 ± 0.98) × 105 | 0 | 99.80d | 100d |
All groups received AG83 on day 0, and splenic and liver parasite burdens were counted on day 180. Mice were primed with UR6 on days 90, 60, and 30 before infection.
P < 0.025.
P < 0.05.
P < 0.005.