TABLE 5.
Parasite burdens in spleens and livers of BALB/c mice given live or sonicated UR6 after infection with L. donovani AG83a
Group | Priming of infected mice with 109 UR6 organisms | Parasite count (mean ± SD) in:
|
% Reduction in parasite burden with respect to group A in:
|
||
---|---|---|---|---|---|
Spleen | Liver | Spleen | Liver | ||
A | (1.50 ± 0.10) × 108 | (3.70 ± 0.26) × 108 | |||
B | Live UR6 | (3.80 ± 1.25) × 106 | (6.40 ± 0.36) × 107 | 97.46b | 82.70b |
C | Sonicated UR6 | (6.20 ± 0.37) × 106 | (5.71 ± 2.81) × 107 | 95.66b | 84.56b |
All groups received AG83 on day 0, and splenic and liver parasite burdens were counted on day 165. Mice were primed with UR6 on days 30, 60, and 90 after infection.
P < 0.005.