Abstract P228 – Table 1. Participants included for each virological outcome and multivariate analysis of factors associated with viral blip, low‐level viraemia, virological failure and virological suppression. Models were adjusted for gender, age, year of ART initiation, HIV transmission route, ethnicity, HBV and HCV status, body mass index, smoking status, origin region, prior AIDS diagnosis, baseline HIV‐1 RNA, baseline CD4+ T‐cell count and initial ART classes. | |||||
---|---|---|---|---|---|
Virological outcome | Viral blip | Low‐level viraemia | Virological failure | Virological suppression week 48 | Virological suppression week 96 |
N included | 2977 | 2977 | 3116 | 3055 | 2435 |
N with endpoint | 448 | 113 | 162 | 2767 | 2262 |
% (95% CI) | N/A | N/A | N/A | 90.6 (89.5 to 91.6) | 92.9 (91.9 to 93.9) |
K‐M % at 12 months (95% CI) | 10.9 (7.9 to 13.9) | 3.2 (1.5 to 4.9) | 4.7 (2.7 to 6.7) | N/A | N/A |
Multivariate analysis | Adjusted HR (95% CI), p‐value | Adjusted HR (95% CI) p‐value | Adjusted HR (95% CI) p‐value | Adjusted OR (95% CI) p‐value | Adjusted OR (95% CI) p‐value |
HIV viral load, HIV‐1 RNA copies/mL | |||||
10 000 or under | 0.52 (0.36 to 0.75), <0.001 | 0.45 (0.17 to 1.18), 0.10 | 0.70 (0.44 to 1.11), 0.13 | 1.41 (0.91 to 2.20), 0.13 | 1.18 (0.69 to 2.00), 0.55 |
10 001 to 100 000 | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
>100 000 | 1.94 (1.55 to 2.42), <0.001 | 2.54 (1.58 to 4.07), <0.001 | 0.90 (0.61 to 1.32), 0.58 | 0.51 (0.37 to 0.70), <0.001 | 0.57 (0.38 to 0.84), 0.004 |
CD4+ T‐cell count, cells/μL | |||||
200 or under | 2.84 (2.07 to 3.89), <0.001 | 7.87 (3.40 to 18.20), <0.001 | 2.94 (1.78 to 4.87), <0.001 | 0.42 (0.28 to 0.62), <0.001 | 0.40 (0.24 to 0.66), <0.001 |
201 to 350 | 2.07 (1.51 to 2.82), <0.001 | 5.13 (2.19 to 11.98), <0.001 | 1.02 (0.58 to 1.79), 0.95 | 0.63 (0.41 to 0.95), 0.03 | 0.57 (0.34 to 0.93), 0.02 |
351 to 500 | 1.33 (0.96 to 1.85), 0.09 | 3.13 (1.29 to 7.60), 0.01 | 1.34 (0.82 to 2.20), 0.25 | 0.93 (0.60 to 1.44), 0.75 | 1.35 (0.76 to 2.39), 0.31 |
>500 | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
K‐M, Kaplan‐Meier; N, number of participants; N/A, not applicable.