| Abstract P242 – Table 1. OR of non‐response after third dose according to CD4 count (Panel A) and to CD4/CD8 ratio (Panel B) at the time of vaccination from fitting a logistic regression analysis. | |||||
|---|---|---|---|---|---|
| Logistic regression of the probability of anti‐S response post full 3 doses vaccination cycle | |||||
| Unadjusted | Adjusteda | ||||
| Panel A | odds ratio (95% CI) | p‐value | odds ratio (95% CI) | p‐value | Type III p‐valueb |
| CD4 count | |||||
| Undetectable ‐ after 3rd dose | |||||
| HCD4 | 1 | 1 | 0.451 | ||
| ICD4 | 1.83 (0.11 to 29.41) | 0.671 | 1.53 (0.09 to 25.78) | 0.767 | |
| LCD4 | 18.51 (2.13 to 160.8) | 0.008 | 4.41 (0.33 to 59.31) | 0.264 | |
| Low level (below 46 BAU/mL) ‐ after 3rd dose | |||||
| HCD4 | 1 | 1 | 0.005 | ||
| ICD4 | 0.99 (0.48 to 2.06) | 0.985 | 0.95 (0.45 to 1.99) | 0.893 | |
| LCD4 | 4.40 (2.29 to 8.46) | <0.001 | 3.43 (1.58 to 7.44) | 0.002 | |
| Panel B | |||||
| Undetectable ‐ 3rd dose | |||||
| HR | 1 | 1 | 0.292 | ||
| IR | − | − | |||
| LR | 3.98 (0.48 to 33.40) | 0.203 | 1.14 (0.10 to 13.25) | 0.914 | |
| Low level (below 46 BAU/mL) ‐ after 3rd dose | |||||
| HR | 1 | 1 | 0.082 | ||
| IR | 1.34 (0.22 to 8.13) | 0.749 | 1.30 (0.21 to 7.94) | 0.777 | |
| LR | 5.14 (1.16 to 22.78) | 0.031 | 3.77 (0.81 to 17.47) | 0.090 | |
HCD4, CD4 >500/mm3; HR, ≥1; ICD4, CD4 201‐500/mm3; IR, CD4/CD8 ratio 0.60‐0.99; LCD4, CD4 <200/mm3; LR, CD4/CD8 ratio 0‐0.59.
aAdjusted for age, CD4 nadir, VL 50 copies/mL at T0 and no. of comorbidities;
bfrom the adjusted model.