Abstract O46 – Table 1. Change in total lymphocyte counts and CD4+ T‐cell counts in treatment‐naïve participants with HIV‐1, MK‐8591‐011 parts 1 and 2 (through week 72).
Total lymphocyte counts (109 cells/L)
Treatment group	N	Mean % change from baseline (95% CI)a
DOR/3TC/TDF	22	15.9 (2.0, 29.9)
ISL 0.25 mg + DOR 100 mg (+/‐ 3TC)	19	20.5 (4.3, 36.6)
ISL 0.75 mg + DOR 100 mg (+/‐ 3TC)	19	‐0.4 (‐14.9, 14.1)
ISL 2.25 mg + DOR 100 mg (+/‐ 3TC)	16	‐15.9 (‐31.9, 0.1)
CD4+ T‐cell counts (cells/mm3)
Treatment group	N	Mean % change from baseline (95% CI)a
DOR/3TC/TDF	22	60.1 (40.2, 80.0)
ISL 0.25 mg + DOR 100 mg (+/‐ 3TC)	19	79.8 (50.0, 109.6)
ISL 0.75 mg + DOR 100 mg (+/‐ 3TC)	18	47.1 (26.1, 68.2)
ISL 2.25 mg + DOR 100 mg (+/‐ 3TC)	16	24.0 (4.7, 43.4)

^aThe within‐group 95% CIs were calculated based on the t‐distribution.