Abstract P066 – Table 1. Baseline characteristics of experienced patients in study. | |||
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Variables at enrolment | Doravirine n = 128 mean SD or n (%) or median (IQR) | Rilpivirine n = 331 mean SD or n (%) or median (IQR) | p |
Age, years | 53.6±12.4 | 42.3±9.3 | <0.0001 |
Sex, M | 91 (71.1%) | 237 (71.6%) | 0.91 |
BMI, kg/m2 | 26.2±5.5 | 24.4±3.8 | 0.0002 |
Weight, kg | 77.3±17.6 | 81.7±14.3 | 0.0007 |
Caucasian | 117 (91.4%) | 304 (91.8%) | 0.88 |
Risk factor for HIV acquisition: sexual | 89 (69.5%) | 244 (73.7%) | 0.16 |
Risk factor for HIV acquisition: IDU | 24 (18.8%) | 66 (19.9%) | 0.16 |
Risk factor for HIV acquisition: other/ND | 15 (11.7%) | 21 (6.3%) | 0.16 |
HBV coinfection (n = 102/321) | 8 (7.8%) | 20 (6.2%) | 0.57 |
HCV coinfection (n = 107/329) | 26 (24.3%) | 76 (23.1%) | 0.80 |
Detectable HIV‐RNA | 16 (12.5%) | 50 (15.1%) | 0.48 |
Previous ART: PI | 29 (22.7%) | 152 (45.9%) | <0.0001 |
Previous ART: INSTI | 62 (48.4%) | 17 (5.1%) | <0.0001 |
Previous ART: NNRTI | 47 (36.7%) | 151 (45.6%) | 0.08 |
CD4, cells/mm3 | 685 (493 to 955) | 624 (443 to 820) | 0.02 |
Total cholesterol, mg/dL | 198±45 | 189±42 | 0.06 |
HDL‐cholesterol, mg/dL | 51±15 | 48±16 | 0.08 |
LDL‐cholesterol, mg/dL | 118±38 | 112±38 | 0.12 |
Triglycerides, mg/dL | 114 (85 to 153) | 120 (85 to 172) | 0.56 |
On lipid‐lowering drugs | 25 (19.5%) | 29 (8.8%) | 0.001 |
AST, UI/dL | 21 (18 to 29) | 24 (19 to 31) | 0.008 |
ALT, UI/dL | 24 (17 to 32) | 28 (21 to 42) | 0.0007 |