| Abstract P107 – Table 1. Clinical/demographic characteristics and outcome of HIV‐1 infected patients, ART experienced with HIV‐RNA level <50 copies/mL switching to DOR/TDF/3TC at the Infectious and Tropical Diseases Unit in a tertiary teaching hospital in Florence, Italy. | ||
|---|---|---|
| Italians, n (%) | 35 | 66.0 |
| Gender, n (%) | ||
| Female | 4 | 7.5 |
| Male | 43 | 81.3 |
| Transgender | 6 | 11.3 |
| Age at entry, median [IQR] | 52 | 44 to 58 |
| Risk of HIV transmission, n (%) | ||
| Heterosexual | 15 | 28.3 |
| MSM | 31 | 58.5 |
| IVDU | 3 | 5.7 |
| Other/not known | 4 | 7.5 |
| Cardiovascular disease | 9 | 16.9 |
| Diabetes | 4 | 7.5 |
| Dyslipidaemia | 13 | 24.5 |
| Mental disorders | 5 | 9.4 |
| No comorbidity | 7 | 13.2 |
| Years of undetectable viraemia, median [IQR] | 6 | [2 to 9] |
| AIDS diagnosis, n (%) | 15 | 28.3 |
| Previous virological failure | 3 | 5.7 |
| HBsAg positivity, n (%) | 3 | 5.7 |
| HIV‐RNA zenith, log 10 copies/mL, median [IQR] | 5.0 | 4.6 to 5.4 |
| Nadir CD4 (cells/mL), median [IQR] | 350 | 131 to 477 |
| Years of HIV, median [IQR] | 10 | 4 to 18 |
| Years of antiretroviral therapy, median [IQR] | 9 | 4 to 16 |
| CD4+ T cells at baseline/μL, median [IQR] | 697 | 525 to 923 |
| Type of pre‐switch regimen | ||
| NNRTI | 30 | 56.6 |
| PI | 5 | 9.4 |
| INSTI | 14 | 26.4 |
| Other | 4 | 7.5 |
| Number of previous ART regimens, median [IQR] | 3 | 2 to 5 |
| Type of pre‐switch backbone | ||
| 3TC/ABC | 3 | 5.6 |
| FTC/TAF | 34 | 64.1 |
| FTC/TDF | 12 | 22.6 |
| 3TC | 3 | 5.7 |
| No backbone | 1 | 1.9 |
| Major drug resistance on historical genotypea | ||
| Low‐level resistance TDF | 1 out of 31 | 3.23 |
| Low‐level/potential low‐level resistance DOR | 4 out of 31 | 12.9 |
| High‐level resistance 3TC | 3 out of 31 | 9.7 |
| Discontinuation for all causes | 7 | 13.2 |
| Virological failure | 1 | |
| Gastrointestinal toxicity | 3 | |
| Itchy | 2 | |
| Rash | 1 | |
aHistorical genotype available in 31 out of 53 patients.