| Abstract P150 – Table 1. Descriptives of sociodemographic and metabolic variables at baseline and their change between week 48 and baseline. | |||||||
|---|---|---|---|---|---|---|---|
| ITT‐E | N | Missing | Dovato (N = 87) | Biktarvy (N = 43) | pa | 95% CI lower limit | 95% CI upper limit |
| Baseline | |||||||
| Gender, N male/N female | 130 | 0 | 79/8 | 39/4 | 0.984 | ||
| Age (y), mean ± SD | 130 | 0 | 47.31 ± 11.94 | 44.98 ± 11.60 | 0.292 | ‐2.03 | 6.70 |
| Weight (kg), mean ± SD | 130 | 0 | 81.21 ± 12.39 | 75.30 ± 13.00 | 0.013 | 1.26 | 10.55 |
| Waist (cm), mean ± SD | 128 | 2 | 95.35 ± 11.78 | 89.21 ± 11.20 | 0.006 | 1.82 | 10.46 |
| BMI, median (IQR) | 130 | 0 | 25.95 (23.37 to 28.43) | 24.78 (21.78 to 26.13) | 0.024 | 0.02 | 0.03 |
| CD4 (cells/μL), median (IQR) | 127 | 3 | 697.00 (554.25 to 931.25) | 670.00 (522.00 to 916.00) | 0.534 | 0.53 | 0.55 |
| Fasting glucose (mg/dL), median (IQR) | 118 | 12 | 88.5 (81.00 to 97.50) | 89.50 (80.25 to 96.00) | 0.789 | 0.79 | 0.81 |
| Fasting insulin (mU/L), median (IQR) | 117 | 13 | 9.40 (7.03 to 12.00) | 8.60 (5.05 to 12.00) | 0.203 | 0.20 | 0.21 |
| HOMA_IR, median (IQR) | 113 | 17 | 2.09 (1.44 to 2.84) | 1.95 (1.04 to 2.79) | 0.243 | 0.24 | 0.26 |
| Triglycerides (mg/dL), median (IQR) | 123 | 7 | 102.00 (79.00 to 141.50) | 103.00 (72.00 to 151.00) | 0.846 | 0.84 | 0.85 |
| Cholesterol (mg/dL), mean ± SD | 124 | 6 | 188.66 ± 36.73 | 193.36 ± 37.19 | 0.503 | ‐18.56 | 9.15 |
| Cholesterol_HDL (mg/dL), median (IQR) | 123 | 7 | 47.00 (40.00 to 55.00) | 49.00 (39.75 to 54.25) | 0.707 | 0.71 | 0.72 |
| Cholesterol_LDL (mg/dL), median (IQR) | 122 | 8 | 117.00 (100.50 to 136.75) | 123.00 (105.75 to 138.00) | 0.546 | 0.54 | 0.56 |
| DXA_lean body (g), mean ± SD | 130 | 0 | 55 540.95 ± 7349.08 | 53 282.33 ± 8858.59 | 0.126 | ‐646.57 | 5163.83 |
| DXA_lean trunk (g), mean ± SD | 130 | 0 | 27 887.73 ± 3943.05 | 26 514.77 ± 4618.68 | 0.080 | ‐167.67 | 2913.57 |
| DXA_lean limb (g), mean ± SD | 117 | 13 | 24 324.17 ± 3428.40 | 23 295.12 ± 4006.26 | 0.153 | ‐388.26 | 2446.36 |
| DXA_trunk fat (g), median (IQR) | 130 | 0 | 11 099.00 (8353.90 to 14 437.50) | 9477.40 (6353.50 to 12 929.40) | 0.018 | 0.02 | 0.02 |
| DXA_limb fat (g), median (IQR) | 129 | 1 | 10 557.20 (8347.15 to 12 937.40) | 8744.10 (6658.30 to 11 246.30) | 0.007 | 0.01 | 0.01 |
| Fat percentage, median (IQR) | 130 | 0 | 29.50 (24.10 to 33.70) | 25.90 (21.30 to 30.40) | 0.015 | 0.01 | 0.02 |
| Total fat mass (g), median (IQR) | 130 | 0 | 23 029.20 (18 071.20 to 2907.70) | 20 176.60 (14 843.80 to 24 862.60) | 0.010 | 0.01 | 0.01 |
| Delta week 48 to baseline | |||||||
| Weight (kg), mean ± SD | 117 | 13 | 0.33 ± 4.91 | 0.17 ± 3.48 | 0.861 | ‐1.59 | 1.90 |
| Waist (cm), mean ± SD | 116 | 14 | 0.09 ± 4.68 | 0.90 ± 3.73 | 0.352 | ‐2.53 | 0.91 |
| BMI, median (IQR) | 117 | 13 | ‐0.06 (‐0.72 to 0.81) | 0.08 (‐0.59 to 0.46) | 0.954 | 0.96 | 0.96 |
| CD4 (cells/μL), median (IQR) | 110 | 20 | ‐10.00 (‐79.00 to 93.00) | ‐50.00 (‐134.00 to 72.50) | 0.097 | 0.09 | 0.10 |
| Fasting glucose (mg/dL), median (IQR) | 99 | 30 | ‐4.00 (‐12.00 to 6.00) | 0.00 (‐7.00 to 6.00) | 0.240 | 0.23 | 0.25 |
| Fasting insulin (mU/L), median (IQR) | 95 | 35 | ‐0.45 (‐2.75 to 2.23) | ‐0.60 (‐4.70 to 1.00) | 0.229 | 0.22 | 0.24 |
| HOMA_IR, median (IQR) | 91 | 39 | ‐0.07 (‐0.70 to 0.53) | ‐0.21 (‐0.86 to 0.27) | 0.306 | 0.30 | 0.32 |
| Triglycerides (mg/dL), median (IQR) | 105 | 25 | ‐7.00 (‐33.50 to 25.50) | ‐5.00 (‐33.00 to 8.00) | 0.568 | 0.56 | 0.58 |
| Cholesterol (mg/dL), mean ± SD | 110 | 20 | ‐2.25 ± 27.61 | ‐11.00 (‐37.00 to 11.50) | 0.182 | ‐3.89 | 20.27 |
| Cholesterol_HDL (mg/dL), median (IQR) | 109 | 21 | 0.00 (‐4.00 to 4.00) | ‐4.00 (‐7.50 to 1.00) | 0.016 | 0.01 | 0.02 |
| Cholesterol_LDL (mg/dL), median (IQR) | 104 | 26 | 0.00 (‐16.00 to 13.65) | ‐7.00 (‐30.60 to 8.50) | 0.196 | 0.19 | 0.21 |
| DXA_lean body (g), mean ± SD | 118 | 12 | 132.29 ± 2268.77 | ‐640.01 ± 2496.40 | 0.095 | ‐136.95 | 1681.55 |
| DXA_lean trunk (g), mean ± SD | 116 | 14 | 95.19 ± 1248.99 | ‐499.53 ± 1529.56 | 0.028 | 67.04 | 1122.40 |
| DXA_lean limb (g), mean ± SD | 105 | 25 | ‐84.42 ± 1553.71 | ‐255.19 ± 1056.13 | 0.564 | ‐413.89 | 755.42 |
| DXA_trunk fat (g), median (IQR) | 116 | 14 | 144.70 (‐775.15 to 1000.30) | 616.90 (‐308.10 to 1513.70) | 0.062 | 0.06 | 0.07 |
| DXA_limb fat (g), median (IQR) | 117 | 13 | 45.05 (‐583.15 to 612.15) | 387.30 (‐260.90 to 897.20) | 0.174 | 0.16 | 0.18 |
| Fat percentage, median (IQR) | 116 | 14 | 0.10 (‐1.70 to 1.60) | 1.00 (‐0.40 to 2.70) | 0.016 | 0.01 | 0.02 |
| Total fat mass (g), median (IQR) | 117 | 13 | 291.50 (‐1324.40 to 1760.30) | 755.35 (‐679.05 to 2383.25) | 0.152 | 0.14 | 0.16 |
aUnpaired Student's t tests (when the data were normally distributed according to the Shapiro Wilk test of normality) or Mann‐Whitney U tests (in the other cases).