Abstract P153 – Table 1. Factors impacting probability of weight change category after switch to doravirine.
	Studies 018+021	Studies 018+021	Study 024	Study 024
Weight loss vs weight gain variable	OR (95% CI)	p‐value	OR (95% CI)	p‐value
Non‐Black vs Black	6.14 (1.53, 24.60)	0.010	2.37 (0.78, 7.17)	0.126
Non‐Black vs Black, Female	−		6.02 (1.15, 31.51)	0.033
Non‐Black vs Black, Male	−		0.93 (0.23, 3.81)	0.923
Female vs Male	4.76 (1.52, 14.87)	0.007	1.93 (0.60, 6.21)	0.272
Female vs Male, Non‐Black	−		4.89 (1.66, 14.39)	0.004
Female vs Male, Black	−		0.76 (0.11, 5.39)	0.782
Age <50 vs ≥50y	3.45 (0.71, 16.68)	0.124	0.80 (0.39, 1.63)	0.540
Baseline weight	1.06 (1.02, 1.10)	0.003	1.04 (1.01, 1.08)	0.009
Prior regimen: NNRTI vs PI	0.76 (0.36, 1.58)	0.460	0.41 (0.18, 0.95)	0.038
Time of switch: Day 1 vs Week 24	−		0.48 (0.25,0.94)	0.033
Stable weight vs weight gain variable	OR (95% CI)	p‐value	OR (95% CI)	p‐value
Non‐Black vs Black	2.15 (1.18, 3.91)	0.012	1.43 (0.67, 3.06)	0.359
Non‐Black vs Black, Female	−		2.47 (0.77, 7.85)	0.127
Non‐Black vs Black, Male	−		0.83 (0.31, 2.19)	0.703
Female vs Male	1.37 (0.67, 2.79)	0.383	1.01 (0.45, 2.27)	0.982
Female vs Male, Non‐Black	−		1.74 (0.73, 4.18)	0.214
Female vs Male, Black	−		0.58 (0.16, 2.13)	0.416
Age <50 vs ≥50y	1.14 (0.57, 2.30)	0.706	0.60 (0.37, 0.98)	0.043
Baseline weight	1.01 (0.99, 1.03)	0.471	1.03 (1.01, 1.06)	0.016
Prior regimen: NNRTI vs PI	0.60 (0.39, 0.92)	0.021	0.94 (0.58, 1.54)	0.815
Time of switch: Day 1 vs Week 24	−		0.72 (0.46, 1.11)	0.132

Odds ratios, 95% CIs and p‐values were from a generalized logistic model with the status of weight change (loss, stable and gain) as its outcome variable, and study ID, race, sex, age group, baseline BMI group and baseline weight as its explanatory variables. For P024, the model also included interaction of race and sex, categories of prior ART, and duration of prior ART as explanatory variables. The interaction term was not included in the model for P018‐021 as there were no black females in the weight loss category.