| Abstract P155 – Table 1. Slopes from fitting a step‐linear mixed model with change at 1 year after the switch. | ||||||
|---|---|---|---|---|---|---|
| Pre‐switch | 0 to 1 year after switch | >1 year after switch | ||||
| Laboratory parameter | Mean | p‐valuea | Mean | p‐valuea | Mean | p‐valuea |
| Metabolic profile | ||||||
| LDL Chol | 3.5 (2.7 to 4.2) | <0.001 | 7.8 (6.1 to 9.5) | <0.001 | ‐16.2 (‐18.9 to 13.4) | <0.001 |
| T‐Chol | 4.2 (3.6 to 4.9) | <0.001 | 10.2 (8.7 to 11.8) | <0.001 | ‐21.1 (‐23.6 to ‐18.5) | <0.001 |
| Triglycerides | 1.4 (‐0.6 to 3.3) | 0.163 | 10.5 (5.7 to 15.3) | <0.001 | ‐14.3 (‐22.1 to ‐6.6) | <0.001 |
| T‐Chol/HDL Chol ratio | ‐0.0 (‐0.1 to 0.0) | 0.080 | 0.1 (0.0 to 0.2) | 0.020 | ‐0.2 (‐0.3 to ‐0.1) | 0.006 |
| Glucose | ‐0.3 (‐0.6 to 0.1) | 0.176 | 2.5 (1.6 to 3.4) | <0.001 | ‐2.5 (‐3.9 to ‐1.0) | <0.001 |
| Hepatic profile | ||||||
| ALT | 3.1 (‐0.0 to 6.1) | 0.051 | ‐24.4 (‐32.5 to ‐16.3) | <0.001 | 30.3 (17.3 to 43.4) | <0.001 |
| AST | 1.5 (‐0.5 to 3.4) | 0.146 | ‐12.7 (‐17.9 to ‐7.5) | <0.001 | 17.2 (8.8 to 25.7) | <0.001 |
| GGT | ‐1.3 (‐2.7 to 0.1) | 0.070 | ‐4.6 (‐8.0 to ‐1.2) | 0.008 | 5.9 (0.4 to 11.4) | 0.035 |
| ALP | ‐2.6 (‐3.7 to ‐1.4) | <0.001 | ‐13.6 (‐16.3 to ‐10.9) | <0.001 | 22.9 (18.4 to 27.4) | <0.001 |
| Renal profile | ||||||
| Creatinine | ‐0.0 (‐0.1 to 0.0) | 0.101 | 0.1 (‐0.0 to 0.1) | 0.172 | ‐0.1 (‐0.2 to 0.0) | 0.185 |
| Egfr | ‐2.6 (‐2.8 to ‐2.4) | <0.001 | 2.3 (1.7 to 2.8) | <0.001 | ‐1.5 (‐2.4 to ‐0.6) | <0.001 |
ALP, alcaline phosphatase; ALT, alanine aminotransferase; AST, aspartate transaminase; eGFR, estimated glomerular filtration rate; GGT, gamma glutamyl transpeptidase; HDL Chol, high‐density lipoprotein cholesterol; LDL Chol, low‐density lipoprotein cholesterol; T‐Chol, total cholesterol.
aWald test.