Abstract P161 – Table 1. Changes in metabolic and renal parameters.
Parameter	Baseline N = 147	6 months N = 146	12 months N = 137
Total cholesterol, mg/dL
Mean (95% CI)	182.8 (176.3 to 189.2)	173.3 (166.8 to 179.8)	175.2 (168.6 to 181.8)
Change from baseline (95% CI); p‐value		‐9.45 (‐16.43 to ‐2.48); p = 0.004	‐7.54 (‐14.67 to ‐0.41); p = 0.034
LDL cholesterol, mg/dL
Mean (95% CI)	46.46 (44.48 to 48.44)	45.60 (43.62 to 47.58)	43.91 (41.90 to 45.92)
Change from baseline (95% CI); p‐value		‐0.855 (‐2.65 to 0.94); p = 0.761	‐2.55 (‐4.39 to ‐0.70); p = 0.003
Triglycerides, mg/dL
Mean (95% CI)	155.74 (138.95 to 172.53)	135.89 (119.10 to 152.68)	144.75 (127.51 to 161.99)
Change from baseline (95% CI); p‐value		‐19.85 (‐41.92 to 2.22); p = 0.093	‐10.98 (‐33.58 to 11.60); p = 0.727
TC:HDL ratio
Mean (95% CI)	4.12 (3.93 to 4.30)	3.89 (3.71 to 4.08)	4.14 (3.95 to 4.33)
Change from baseline (95% CI); p‐value		‐0.22 (‐0.44 to ‐0.001); p = 0.048	0.02 (‐0.20 to 0.24); p = 1.0
Glucose, mg/dL
Mean (95% CI)	99.23 (94.80 to 103.67)	101.56 (97.13 to 105.99)	102.86 (98.37 to 107.34)
Change from baseline (95% CI); p‐value		2.32 (‐6.37 to 1.72); p = 0.50	3.62 (‐7.76 to 0.52); p = 0.1088
Creatinine, mg/dL
Mean (95% CI)	0.93 (0.89 to 0.96)	0.96 (0.92 to 0.99)	0.96 (0.93 to 1.0)
Change from baseline (95% CI); p‐value		0.03 (0.009 to 0.05); p = 0.0025	0.03 (0.013 to 0.06); p < 0.001
CKD‐EPI, mg/min
Mean (95% CI)	85.71 (83.60 to 87.82)	83.84 (81.73 to 85.95)	82.97 (80.84 to 85.10)
Change from baseline (95% CI); p‐value		‐1.87 (‐3.62 to ‐0.11); p=0.0319	‐2.73 (‐4.52 to ‐0.95); p < 0.001
TyG ratio
Mean (95% CI)	8.79 (8.69 to 8.89)	8.64 (8.55 to 8.74)	8.74 (8.64 to 8.84)
Change from baseline (95% CI); p‐value		‐0.147 (‐0.25 to ‐0.04); p = 0.0023	‐0.005 (‐0.158 to 0.005); p = 0.7387

Multiple comparisons adjusted using the Bonferroni method.