| Abstract P162 – Table 1. Change from baseline by naive status. | |||||||
|---|---|---|---|---|---|---|---|
| Experienced | Experienced | Experienced | Naive | Naive | Naive | pa | |
| T0 mean SD or median (IQR) or N (%) | T1 mean SD or median (IQR) or N (%) | T1‐T0 mean (95% CI) | T0 mean SD or median (IQR) or N (%) | T1 mean SD or median (IQR) or N (%) | T1‐T0 mean (95% CI) | ||
| Weight, kg | 75.6±15.2 | 76.0±13.8 | 0.3 (‐0.2 to 0.8) | 69.9±12.5 | 71.9±12.3 | 1.4 (0.4 to 2.2)b | 0.04 |
| Total cholesterol, mg/dL | 194±42 | 188±40 | ‐5.4 (‐8.6 to ‐2.2)b | 171±46 | 183±38 | 15.0 (7.3 to 22.6)b | <0.0001 |
| LDL‐c, mg/dL | 111±38 | 108±35 | ‐2.5 (‐5.5 to 0.4) | 99±38 | 108±31 | 9.8 (3.4 to 16.2)b | 0.001 |
| HDL‐c, mg/dL | 54±19 | 55±18 | 0.1 (‐1.0 to 1.3) | 48±19 | 52±17 | 4.8 (1.9 to 7.8)b | 0.002 |
| TGL, mg/dL | 115 (85 to 170) | 104 (76 to 153) | ‐13.1 (‐20.4 to ‐5.8)b | 97.5 (77 to 149) | 99 (77 to 131) | 0 (‐13.5 to 13.5) | 0.09 |
| BG in nondiabetic | 93±17 | 96±21 | 2.2 (0.5 to 4.0)b | 89±13 | 89±12 | 0.4 (‐2.6 to 0.4) | 0.29 |
| BG in diabetic | 165±72 | 168±70 | 2.3 (‐30.2 to 34.9) | 170±26 | 173±72 | 32 (‐108 to 171) | 0.53 |
| eGFR mL/min | 86.3±21.9 | 83.5±20.5 | ‐2.5 (‐2.9 to ‐1.1)b | 105.1±29.4 | 89.9±23.7 | ‐15.3 (‐19.9 to ‐10.8)b | <0.0001 |
| AST IU/L | 22 (18 to 27) | 23 (18 to 28) | ‐0.6 (‐3.4 to 2.1) | 25 (19 to 31) | 22 (19 to 27) | ‐3.8 (‐7.8 to 0.3) | 0.22 |
| ALT IU/L | 22 (16 to 31) | 23 (16 to 34) | 2.4 (0.8 to 4.0)b | 23 (17 to 31) | 19 (14 to 26) | ‐5.8 (‐11.0 to ‐0.7)b | 0.0002 |
| acNASH | (N = 311) | (n = 272) | ‐0.22 (‐0.70 to 0.25) | (N = 77) | (N = 70) | ‐0.95 (‐1.55 to ‐0.35)b | 0.059 |
| <4.15 | 272 (87.5%) | 242 (89.0%) | —————————— | 52 (67.5%) | 62 (88.6%) | ———————————— | ————————————‐ |
| 4.15 to 7.73 | 33 (10.6%) | 23 (8.5%) | ——————————— | 21 (27.3%) | 7 (10.0%) | ——————————‐ | ————————————‐ |
| ≥7.74 | 6 (1.9%) | 7 (2.6%) | ——————————– | 4 (5.2%) | 1 (1.4%) | ——————————– | ————————————– |
acNASH, AST/creatinine Non Alcoholic Steato‐Hepatitis score; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BG, basal glucose; eGFR, estimated glomerular filtration rate; HDL‐c, high density lipoprotein‐cholesterol; IQR, interquartile range; IU, international unit; LDL‐c, low density lipoprotein‐cholesterol; SD, standard deviation; TGL, triglycerides.
aT1‐T0 comparison by naïve status;
bp < 0.05 for change from baseline.