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. 2022 Oct 20;148(12):1111–1119. doi: 10.1001/jamaoto.2022.3269

Table 2. Factors Associated With Excess Survivorship Cost in Head and Neck Cancer, 2006 to 2018.

Factors Excess survivorship cost, estimate (95% CI), $/moa
Total cost Out-of-pocket cost
Male sex 0 [Reference] 0 [Reference]
Female sex 318.2 (98.9 to 537.5) 9.6 (4.2 to 15.0)
Age group, y
≥60 0 [Reference] 0 [Reference]
<40 118.1 (−340.9 to 577.2) −7.3 (−18.6 to 4.0)
40-44 −394.0 (−832.2 to 44.1) −19.9 (−30.7 to −9.1)
45-49 −243.7 (−581.9 to 94.5) −5.5 (−13.9 to 2.8)
50-54 −434.4 (−713.6 to −155.3) −6.3 (−13.2 to 0.6)
55-59 −218.3 (−467.2 to 30.5) −5.4 (−11.6 to 0.7)
Employment status
Active 0 [Reference] 0 [Reference]
Other/unknown 21.8 (−181.9 to 225.5) 11.7 (6.7 to 16.7)
Retiree 37.4 (−275.7 to 350.5) −8.0 (−15.8 to −0.3)
Health plan type
PPO 0 [Reference] 0 [Reference]
CDHP/HDHP −456.3 (−767.2 to −145.5) 18.1 (10.4 to 25.7)
Comprehensive −63.9 (−537.5 to 409.6) −14.6 (−26.3 to −2.9)
EPO/missing 507.6 (−33.4 to 1048.7) −27.7 (−41.1 to −14.4)
HMO/POS −151.0 (−385 to 83.1) −39.4 (−45.2 to −33.6)
Region
Northeast 0 [Reference] 0 [Reference]
North Central 52.0 (−242.5 to 346.6) 18.4 (11.1 to 25.7)
South −149.6 (−415.8 to 116.7) 36.9 (30.3 to 43.4)
West −74.4 (−397.6 to 248.8) 19.5 (11.6 to 27.5)
Unknown −2244.3 (−10 892.5 to 6403.9) −35.4 (−248.6 to 177.8)
Residence
Rural 0 [Reference] 0 [Reference]
Urban −133.3 (−387.6 to 121.0) −8.8 (−15.0 to −2.5)
Cancer site
Oral cavity 0 [Reference] 0 [Reference]
Hypopharynx 1991.8 (1180.6 to 2802.9) 21.7 (1.7 to 41.7)
Larynx 227.7 (−118.5 to 573.8) −3.2 (−11.7 to 5.3)
Multiple sites −71.4 (−440.8 to 297.9) 0.1 (−9.0 to 9.2)
Nasopharynx 192.2 (−333.5 to 717.8) 10.3 (−2.6 to 23.3)
Oropharynx −718.0 (−984.7 to −451.4) −13.6 (−20.2 to −7.1)
Other site 0.4 (−348.6 to 349.5) 3.4 (−5.2 to 12.0)
Salivary −537.4 (−927.4 to −147.5) −20.6 (−30.2 to −11.0)
Sinonasal 1116.0 (586.0 to 1645.9) 13.7 (0.7 to 26.8)
Treatment course
RT and CT 0 [Reference] 0 [Reference]
CT only 796.3 (132.4 to 1460.3) −11.7 (−28.0 to 4.7)
RT only −1558.1 (−1841.5 to −1274.8) −22.0 (−29 to −15.1)
Surgery only −1954.5 (−2241.4 to −1667.5) −38.1 (−45.1 to −31.0)
Surgery and CT 2853.3 (1646.0 to 4060.6) 44.7 (14.9 to 74.4)
Surgery and RT −703.8 (−1010.5 to −397.1) −8.4 (−15.9 to −0.8)
Surgery, CT, and RT 2333.6 (2041.0 to 2626.2) 25.5 (18.3 to 32.7)

Abbreviations: CDHP, consumer-driven health plan; CT, chemotherapy; EPO, exclusive provider organization; HDHP, high deductible health plan; HMO, health maintenance organization; POS, point of service; PPO, preferred provider organization; RT, radiation therapy.

a

Models are adjusted for all variables listed and each Elixhauser comorbidity variable.