Table 3.

The impact of secondary hyperparathyroidism treatment on incident dementia stratified by age, sex, race and diabetes status compared with no treatment. Hazard ratios were adjusted for age at diagnosis, sex, race/ethnicity, employment, geographic region, body mass index, dialysis modality type, primary cause of end-stage renal disease, comorbidities (hypertension, diabetes mellitus, cerebrovascular disease, atherosclerotic heart disease, heart failure, peripheral vascular disease, cancer, functional impairment, alcohol dependence and smoking) and days of previous medication prescriptions

Effect modifier	Incident dementia [aHR (95% CI)]
Age	66–69	70–79	≥80
No treatment	Ref	Ref	Ref
Treatment	0.58 (0.54–0.61)	0.58 (0.56–0.60)	0.60 (0.57–0.62)
Pinteraction		.93	.45
Sex	Male	Female
No treatment	Ref
Treatment	0.60 (0.57–0.62)	0.56 (0.54–0.58)
Pinteraction		.01
Race	White	Black	Asian	Other
No treatment	Ref	Ref	Ref	Ref
Treatment	0.61 (0.59–0.62)	0.50 (0.48–0.53)	0.51 (0.46–0.57)	0.62 (0.50–0.75)
Pinteraction		<.001	.01	.86
Diabetes	No	Yes
No treatment	Ref	Ref
Treatment	0.59 (0.56–0.61)	0.57 (0.55–0.59)
Pinteraction		.34