Table 3.

Association between renal function and self-perceived memory decline by physical activity (N = 3223)

	Overall,	Low physical activity,	High physical activity,
CKD stage	OR (95% CI)	OR (95% CI)	OR (95% CI)	P for interaction
No CKD	1 (ref)	1 (ref)	1 (ref)
CKD stages G1–G3	1.41 (1.06, 1.88)	1.60 (1.09, 2.34)	1.15 (0.76, 1.73)	0.24
CKD stages G4 and G5	1.16 (0.51, 2.62)	1.19 (0.47, 3.03)	1.24 (0.13, 11.47)	0.97

Models are adjusted for age, sex, race, education, BMI, depressive symptoms, hypertension, diabetes, CHD, MI, stroke, anemia and smoking. NHANES sampling weights are accounted for in logistic regression analysis to obtain nationally representative estimates. Serum creatinine was measured and used to calculate eGFR with the CKD-EPI equation. CKD stage was then defined by the following cut-points: no CKD: eGFR ≥60 mL/min/1.73 m² and ACR <30 mg/g; CKD stages G1–G3: eGFR 30–59 mL/min/1.73 m² or eGFR ≥60 mL/min/1.73 m² and ACR ≥30 mg/g; CKD stages G4 and G5: eGFR <30 mL/min/1.73 m². Physical activity was collected using the Global Physical Activity Questionnaire and converted to MET·min/week, where ≥600 MET·min/week represents high physical activity.