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. 2022 Jun 29;2(5):469–489. doi: 10.1021/acsbiomedchemau.2c00017

Scheme 3. Synthesis of alkyl substituted stereospecific ether tail derivatives 26a–d.

Scheme 3

Reaction conditions: (a) Alkyl bromide, K2CO3, I2, acetone, 90 °C, 2 h, microwave; (b) TFA, DCM, 0 °C to rt, 3–6 h; )c) N,N′-Di-Boc-1H-pyrazole-1-carboxamidine, DIEA, MeCN, 55 °C, 2–6 h, microwave; (d) TFA, DCM, rt, 4 h.