. 2022 Jun 29;2(5):469–489. doi: 10.1021/acsbiomedchemau.2c00017

Table 1. SphK1 and SphK2 Inhibitory Activities^a.

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SphK activity is presented as percent of control during which no inhibitor is introduced. Recombinant human SphK1 or SphK2 was isolated from cell lysate, and enzyme activity was measured with either 5 μM (SphK1) or 10 μM (SphK2) sphingosine and 250 μM [γ³²P]ATP. Compounds were assayed at 1.0 μM (SphK1) or 0.3 nM (SphK2). All measurements were performed in triplicate.

Compound is a hydrochloride salt.

Compound is a trifluoroacetate salt.

Table 1. SphK1 and SphK2 Inhibitory Activitiesa.

Table 1. SphK1 and SphK2 Inhibitory Activities^a.