Figure 1:

Analysis based on flow cytometry plots from peripheral blood mononuclear cells (PBMCs) from healthy controls (n = 10), and psoriasis patients (n = 30) was performed. Individual cell subsets were sub-gated according to the expression of CD3, CD4, CCR6, CCR4, and CXCR3 surface markers. (A) Representative flow cytometric plots show increased frequencies of Th17.1 and CXCR3⁺-Th17 populations in psoriatic patients compared to healthy controls. (B) Box graphical representation showing different frequencies of CD3⁺CD4⁺CXCR3⁺, Th17.1, and CXCR3⁺-Th17 between patients with psoriasis and healthy controls. Percentages out of origin population from which each population is further sub-gated, as described in Supplementary Fig. S1. Bar graphs showing the mean ± SD. ****P ≤ 0.0001 by Mann–Whitney test or unpaired t-test.