Figure 3:

Analysis of CD3⁺CD4⁻ sub-population based on flow cytometry plots from peripheral blood mononuclear cells (PBMCs) from responding psoriasis patients was conducted (n = 12). Individual cell subsets were sub-gated based on the expression of CD3, CD4, CCR6, CCR4, and CXCR3 surface markers. (A) Representative flow cytometric plots showing changes in T-cell phenotypes in a psoriasis patient at baseline and after anti-IL17 biologic therapy. (B) Box graphical representation showing a significant decrease in CD3⁺CD4⁻CCR6⁺T, CD3⁺CD4^-CCR6⁺CCR4⁺(Tc17), CD3⁺CD4⁻CXCR3⁺T, and CD3⁺CD4⁻CCR6^-CXCR3⁺(Tc1) cell subsets after anti-IL17 biologic therapy in peripheral blood from psoriasis patients. Percentages out of origin population from which each population is further sub-gated. Bar graphs showing the mean ± SD. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 by Wilcoxon signed rank test or paired t-test.