Table 1:
Patient | Gender | Age | Age of disease’s Onset | Previous Treatment* | Washout Period (months) | Current Treatment | Response to treatment | |
---|---|---|---|---|---|---|---|---|
Baseline PASI | 3 months PASI |
|||||||
1 | M | 51 | 48 | cDMARDS, apremilast | 6 | Secukinumab | 21.6 | 0 |
2 | M | 66 | 46 | Naïve | n/a | Secukinumab | 21 | 0.5 |
3 | M | 53 | 29 | Cyclosporine, retinoids | n/a | Secukinumab | 20 | 0 |
4 | M | 53 | 41 | Naïve | n/a | Secukinumab | 11.9 | 0 |
5 | M | 65 | 55 | Cyclosporine, retinoids | n/a | Brodalumab | 18.5 | 1.4 |
6 | F | 38 | 31 | Naïve | n/a | Brodalumab | 10 | 0 |
7 | M | 52 | 48 | Etanercept | 34 | Brodalumab | 12.8 | 1.7 |
8 | M | 70 | 60 | Ustekinumab, secukinumab, apremilast | 1 | Brodalumab | 10 | 20 |
9 | F | 37 | 26 | cDMARDS | n/a | Brodalumab | 8.1 | 0.5 |
10 | M | 49 | 43 | Retinoids, cDMARDS | n/a | Secukinumab | 11.6 | 1.5 |
11 | M | 64 | 25 | Naïve | n/a | Brodalumab | 25.5 | 2.3 |
12 | M | 67 | 60 | Apremilast | 0 | Brodalumab | 30 | 2.8 |
13 | M | 67 | 53 | Adalimumab, cDMARDS, etanercept, cyclosporine, apremilast | 1 | Secukinumab | 10.4 | 0 |
14 | M | 44 | 37 | cDMARDS, cyclosporine, etanercept, ustekinumab | 1 | Secukinumab | 14.1 | 1.2 |
15 | M | 45 | 42 | cDMARDS, adalimumab | 3 | Secukinumab | 13.2 | 0 |
16 | F | 63 | 19 | cDMARDS, cyclosporine, etanercept, ustekinumab | 0 | Secukinumab | 11.9 | 0.5 |
17 | F | 57 | 51 | cDMARDS, cyclosporine, retinoids, ustekinumab | 0 | Secukinumab | 21.2 | 1.8 |
18 | F | 27 | 18 | Naïve | n/a | Secukinumab | 17 | 1.2 |
19 | M | 61 | 32 | cDMARDS, cyclosporine | n/a | Secukinumab | 8.5 | 0 |
20 | M | 41 | 27 | ustekinumab, adalimumab | 13 | Brodalumab | 7.8 | 0 |
21 | M | 50 | 34 | cDMARDS | n/a | Secukinumab | 10.9 | 0.4 |
22 | F | 49 | 36 | cDMARDS, etanercept, ustekinumab | 0 | Brodalumab | 8.5 | 2.8 |
23 | F | 52 | 43 | Retinoids, cDMARDs, ustekinumab, secukinumab | 1 | Brodalumab | 13.5 | 4.6 |
24 | F | 39 | 26 | cDMARDS | n/a | Brodalumab | 18 | 4.1 |
25 | F | 62 | 29 | cDMARDS | n/a | Secukinumab | 8 | 1.8 |
26 | F | 54 | 48 | Naïve | n/a | Secukinumab | 26.6 | 2.2 |
27 | F | 48 | 38 | cDMARDS, etanercept | 1 | Secukinumab | 13.5 | 1.2 |
28 | F | 57 | 35 | ustekinumab | 5 | Brodalumab | 7.2 | 0 |
29 | F | 66 | 46 | cDMARDS, adalimumab | 0 | Secukinumab | 20.5 | 16.2 |
30 | M | 46 | 60 | cDMARDS, etanercept, ustekinumab | 1 | Secukinumab | 11 | 10.5 |
Treatment in chronological order.
Abbreviation: PASI, Psoriasis Area and Severity Index; F, female; M, male; naive patient naïve to biologic treatment; cDMARDs conventional disease-modifying anti-rheumatic drugs; washout period months since last biologic or apremilast therapy; n/a patient has not received prior biologic or apremilast treatment.s