Table 5. Selected Pharmacological Parameters Estimated for Newly Identified CB1 Ligands^a.

		water solubility					cytochrome P450 inhibition
ID	ZINC ID	ESOL LogS	ESOL Class	GI absorption	BBB permeant	Pgp substrate	CYP1A2	CYP2C19	CYP2C9	CYP2D6	CYP3A4
15	ZINC000001531664	–7.17	poorly soluble	low	no	no	no	no	yes	no	no
30	ZINC000217658088	–6.93	poorly soluble	low	no	no	no	yes	no	yes	no
32	ZINC000824654462	–5.01	moderately soluble	high	no	yes	yes	yes	yes	yes	yes
34	ZINC000001832514	–6.63	poorly soluble	low	no	yes	no	no	no	yes	yes
38	ZINC000006040794	–5.90	moderately soluble	high	no	Yes	yes	Yes	no	yes	yes
43	ZINC000263585252	–4.99	moderately soluble	high	no	yes	no	yes	yes	yes	yes

^aBBB, blood–brain barrier; CYP1A2, cytochrome P450 1A2; ESOL, Estimated SOLubility; GI, gastrointestinal; Pgp, P-glycoprotein.