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. 2020 Nov 25;1(1):ltaa008. doi: 10.1093/immadv/ltaa008

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© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Immunology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Vitamin D₃ supplementation is associated with reduced inflammatory monocyte recruitment in response to saline. (A) RNAseq analysis of 3 mm biopsies collected from normal and saline-injected skin (6 hours post-injection) pre- and post-vitamin D₃ supplementation. The top 30 genes upregulated in saline-injected skin as compared to normal skin before pre-Vitamin D₃ and (B) dot plots of top eight upregulated saline-associated genes pre-vitamin D₃. (C) Saline-specific module and (D) monocyte-specific module in saline-injected skin pre- and post-vitamin D₃ supplementation (n = 17). B, analysed by C and D, analysed with a Wilcoxon-matched paired test. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.