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. 2022 Oct 21;41:309. doi: 10.1186/s13046-022-02479-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — MET-CAR-T killing activity on MET highly amplified human cancer cells resistant to MET targeting agents. Analysis of cell viability after 3 days of treatments with different concentrations of anti-MET agents on human gastric carcinoma cells GTL-16_Res cells (A) or Cancer of Unknown Primary L1.13 cells (B). PHA-665752, Capmatinib, JNJ-605: small molecule Tyrosine Kinase Inhibitors targeting MET. MvDN30: a MET inhibitory antibody. Graphs report values as percentage of the untreated controls. (C) MET-CAR specific killing activity at different Effector:Target ratio versus GTL-16_Res (Top panels) and L1.13 (Bottom panel). NTD: Not-transduced T cells, #948/#949: MET-CAR-T. Bars: Standard Deviations. Statistical significance between NTD and MET-CAR-T was calculated by Two-way Anova, corrected Bonferroni. Stars indicated P values: *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001