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. 2022 Oct 21;10:75. doi: 10.1186/s40364-022-00423-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The heatmap and functional enrichment analyses in chronic lymphocytic leukemia (CLL) patients. A The heatmap of differentially expressed miRNAs in CLL patients, CLL cell lines and control. B The heatmap of differentially expressed mRNAs in CLL patients, CLL cell lines and control. C GO analysis results showed that changes in molecular function (MF), cell component (CC) and biological processes (BP) of DEGs between CLL patients and control were mainly enriched in heterocyclic compound binding, organelle part and regulation of gene expression. D KEGG pathway analysis revealed that the DEGs between CLL patients and control were mainly enriched in Notch signaling pathway and JAK-STAT signaling pathway