Table 2.

Association between inflammatory burden index and overall survival of patients with patients with colorectal cancer

Variables	Model a		Model b		Model c
	HR (95%CI)	p value	HR (95%CI)	p value	HR (95%CI)	p value
LCR
Continuous (per SD)	0.824 (0.759,0.895)	< 0.001	0.837 (0.77,0.91)	< 0.001	0.848 (0.781,0.922)	< 0.001
Cutoff value		< 0.001		< 0.001		< 0.001
C1 (< 2813.953)	ref		ref		ref
C2 (≥ 2813.953)	0.551 (0.494,0.616)		0.589 (0.526,0.659)	< 0.001	0.605 (0.54,0.678)
Quartiles
Q1 (< 4.08)	ref		ref		ref
Q2 (4.08–11.37)	0.716 (0.622,0.825)	< 0.001	0.726 (0.629,0.839)	< 0.001	0.744 (0.644,0.86)	< 0.001
Q3 (11.37–65.47)	0.548 (0.473,0.635)	< 0.001	0.581 (0.5,0.675)	< 0.001	0.605 (0.52,0.704)	< 0.001
Q4 (≥ 65.47)	0.437 (0.376,0.508)	< 0.001	0.48 (0.412,0.559)	< 0.001	0.502 (0.43,0.585)	< 0.001
p for trend		< 0.001		< 0.001		< 0.001

Model a: No adjusted

Model b: Adjusted for age, sex, BMI, TNM stage

Model c: Adjusted for age, sex, BMI, TNM stage, tumor type, surgery, radiotherapy, chemotherapy, hypertension, diabetes, smoking, drinking, family history

HR Hazard ratio, 95%CI 95%confidence intervals, NLR Neutrophil-to-lymphocyte ratio