Experimental and predicted BRAF^V600E inhibitory IC₅₀ values of pyrimidine–sulfonamide hybrid derivatives used in current study.

S. No.	R1	X	n	R2	IC50 (nM)	pIC50	Predicted pIC50 values (Gaussian)	Ref.
1		F	1	OH	5.620	8.250	7.802	52
2		F	1	OH	26.300	7.580	7.901	52
3		F	1	OH	30.300	7.519	7.748	52
4		F	1	OH	8.680	8.061	7.858	52
5		F	1	OH	2.490	8.604	8.436	52
6		Cl	1	OH	4.250	8.372	7.824	52
7		Cl	1	OH	21.800	7.662	7.923	52
8		Cl	1	OH	14.800	7.830	7.770	52
9		Cl	1	OH	7.810	8.107	8.464	52
10		—	2	F	22.300	7.652	7.440	51
11		—	3	F	89.000	7.051	7.376	51
12		—	3	F	26.000	7.585	7.575	51
13		—	3	F	25.100	7.600	7.773	51
14		—	3	F	16.200	7.790	7.778	51
15		—	3	F	9.300	8.032	7.778	51
16		—	2		28.300	7.543	7.615	53
17		—	2		59.100	7.228	7.403	53
18		—	2		141.000	6.851	7.323	53
19		—	2		23.400	7.631	7.375	53
20		—	2		16.700	7.777	7.611	53
21		—	2		73.700	7.133	7.598	53
22		—	2		12.700	7.896	8.112	53
23		—	2		152.000	6.818	6.651	53
24		—	3		13.500	7.870	8.067	53
25		—	3		11.400	7.943	7.721	53
26		—	3		20.400	7.690	8.326	53
27		—	3		4.310	8.366	8.332	53
28		—	3		6.210	8.207	8.286	53
29		—	3		24.500	7.611	7.758	53
30		—	3		1.200	8.921	8.331	53
31		—	3		4.310	8.366	8.332	53
32		—	3		6.210	8.207	8.286	53
33		—	3		25.100	7.600	7.507	53
34		—	3		9.300	8.032	7.741	53
35		—	3		131.0	6.883	7.454	53
36		—	3		20.0	7.699	7.453	53
37		—	3		35.0	7.456	7.407	53
38		—	2	—	1910.0	5.719	5.987	54
39		—	2	—	740.0	6.131	6.055	54
40		—	2	—	820.0	6.086	6.066	54
41		—	2	—	910.0	6.041	6.066	54
42		—	2	—	620.0	6.208	6.183	54
43		—	2	—	980.0	6.009	6.043	54
44		—	2	—	790.0	6.102	5.993	54
45		—	3	—	1120.0	5.951	6.045	54
46		—	3	—	530.0	6.276	6.062	54
47		—	3	—	790.0	6.102	6.056	54
48		—	3	—	810.0	6.092	6.043	54
49		—	3	—	490.0	6.310	6.259	54
50		—	3	—	820.0	6.086	6.185	54
51		—	3	—	1280.0	5.893	6.409	54