Contributions of the most important amino acid residues for the binding of T109, T126, T160, T183 and dabrafenib to hBRk.

T109		T126		T160		T183		Dabrafenib (DAB)
Residue	ΔGbind	Residue	ΔGbind	Residue	ΔGbind	Residue	ΔGbind	Residue	ΔGbind
Lys483	−6.86	Lys483	−2.68	Thr529	−3.63	Lys483	−3.09	Gly593	−3.45
Asp594	−3.93	Phe583	−2.27	Lys483	−2.74	Asp594	−2.38	Trp531	−2.63
Ile527	−2.21	Leu514	−2.19	Leu514	−2.43	Val471	−2.08	Phe583	−2.36
Val471	−2.07	Val471	−2.16	Val471	−2.05	Gly593	−2.07	Thr529	−2.23
Phe583	−1.77	Thr529	−1.80	Leu505	−1.85	Ile463	−2.02	Leu514	−1.93
Leu514	−1.51	Ile463	−1.73	Phe583	−1.77	Leu514	−1.97	Val471	−1.89
		Leu505	−1.58	Trp531	−1.62	Ile527	−1.92	Ile527	−1.81
						Phe583	−1.91	Cys532	−1.70
						Leu505	−1.56