TABLE 2.

The average number and percentage of hazardous CDSs are greater in pathogenic groups compared to nonpathogenic Groups.

Organism	Group	Genera/species in group	Average ± SD of # CDSs with hazardous functions (Average % CDSs) a
Neisseria	Pathogenic	N. meningitidis	50 ± 3 (2.3%)
		N. gonorrhoeae	53 ± 3 (2.2%)
	Nonpathogenic	See Table 3	27 ± 5 (1.3%)
Escherichia coli	Pathogenic	EAEC/ETEC/AIEC/EPEC	160 ± 31 (3.2%)
		EHEC	290 ± 20 (5.3%)
		ExPEC	163 ± 32 (3.3%)
	Nonpathogenic	See Table 3	125 ± 26 (2.7%)
Burkholderia	Pathogenic	B. mallei	111 ± 17 (2.1%)
		B. pseudomallei	143 ± 16 (2.1%)
		B. cenocepacia	102 ± 8 (1.5%)
	Nonpathogenic	See Table 3	82 ± 20 (1.2%)
Pseudomonas	Pathogenic	P. aeruginosa and P. mendocina	126 ± 21 (2.3%)
		P. syringae (plant pathogen)	76 ± 3 (1.3%)
	Nonpathogenic	See Table 3	76 ± 7 (1.9%)
Streptococcus	Pathogenic	S. pneumoniae	39 ± 6 (1.9%)
		S. pyogenes	42 ± 3 (2.2%)
		S. suis	33 ± 4 (1.6%)
	Nonpathogenic	See Table 3	20 ± 2 (1.0%)
Bacillus	Pathogenic	B. cereus and others (See Table 3)	59 ± 11 (1.1%)
		B. anthracis	61 ± 3 (1.1%)
	Nonpathogenic	See Table 3	23 ± 10 (0.5%)
Clostridium	Pathogenic	C. botulinum and C. tetani	6 ± 1 (0.3%)
		C. difficile	5 ± 1 (0.2%)
		C. perfringens	5 ± 1 (0.4%)
	Nonpathogenic	See Table 3	1 ± 1 (0.1%)
Mycobacterium	Pathogenic	M. tuberculosis and others (See Table 3)	440 ± 8 (26%)
		M. leprae and others (See Table 3)	281 ± 120 (18%)
	Nonpathogenic	See Table 3	288 ± 19 (12%)

^aCDSs above the 40% threshold as defined in the Methods Section; the fraction of CDSs is defined by the number of hits divided by the total number of CDSs in each strain.

Bold italics represents a significant difference in percentage between the pathogenic and nonpathogenic group as defined by a pairwise t-test (p < 0.05, two-tailed, unequal variance).