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. 2022 Sep 19;11(10):1061–1071. doi: 10.1093/stcltm/szac062

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Tan IIA-NPs increased iNSC survival post-stroke. Twelve weeks post-transplantation, pigs were sacrificed and collected brain tissues underwent immunohistochemistry analysis to assess differences in iNSC survivability between PBS + iNSC and Tan IIA-NP + iNSC pigs. Human HNA + iNSCs colocalized with the cell nucleus marker DAPI at the lesion border (A-C; scale bar = 300 µm; white box scale bar = 10 µm). Quantitative analysis of ipsilateral hemisphere (D; scale bar = 10mm) revealed Tan IIA-NP treatment significantly improved survivability of transplanted iNSCs (4.47 ± 1.03%; E) relative to the PBS + iNSC control group (2.52 ± 1.62%). * indicates a significant (P < .05) difference between treatment groups. Data are expressed as mean ± SD. PBS + PBS data n = 6, PBS + iNSC data n = 6, and Tan IIA-NP + iNSC data n = 6.