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. 2022 Sep 19;11(10):1061–1071. doi: 10.1093/stcltm/szac062

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Tan IIA-NP treatment enhanced iNSC neuronal differentiation. Immunohistochemistry analysis showed human HNA + cells colocalized with the mature neuron protein NeuN at the lesion site 12 weeks post-transplantation (A-D; scale bar = 300 µm; white box; scale bar = 10 µm). Quantitative analysis of PBS + iNSC and Tan IIA-NP + iNSC ipsilateral hemisphere scans (E; scale bar = 10 mm) revealed Tan IIA-NPs increased the number of HNA+/NeuN + cells at 12 weeks post-transplantation (73.96 ± 5.86% vs. 63.61 ± 7.39%, respectively; F). Data are expressed as mean ± SD. * indicates a significant (P < .05) difference between treatment groups. PBS + PBS data n = 6, PBS + iNSC data n = 6, and Tan IIA-NP + iNSC data n = 6.