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. 2022 Sep 19;11(10):1061–1071. doi: 10.1093/stcltm/szac062

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Tan IIA-NP + iNSC treatment improved post-stroke neurological recovery. Post-stroke assessments showed animals demonstrated acute severe disability (top image; A) and improved recovery over time (bottom image). Post-stroke symptoms were assigned a modified Rankin Scale (mRS) score ranging from 0 (no symptoms) to 6 (death; B). mRS scores revealed Tan IIA-NP + iNSC pigs demonstrated decreased mRS scores at 1 week post-transplantation (WPT; C) relative to 5 days post-stroke (DPS) and 1 day post-transplantation (DPT) and at 4 and 12 WPT relative to 2 and 3 DPT. Comparatively, PBS + iNSC and PBS + PBS pigs never demonstrated this level of neurological recovery. At 1, 4, and 12 WPT Tan IIA-NP + iNSC pigs possessed significantly reduced scores compared to PBS + PBS (1.67 ± 1.03 and 1.33 ± 0.82 vs. 3.00 ± 0.00 and 2.67 ± 0.82), but not PBS + iNSC pigs (2.67 ± 1.37 and 2.33 ± 1.51). HPS indicates hours post-stroke. * indicates a significant (P < .05) difference from the pre-stroke time point. # indicates a significant (P < .05) difference from the 0-4 HPS time point. $ indicates a significant (P < .05) difference from the 5 DPS and 1 DPT time points. † indicates a significant (P < .05) difference from the 2 and 3 DPT time points.