| 2.1 Patient‐reported symptom scores—Bausch: LE alone |
6 |
465 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.33 [‐0.51, ‐0.15] |
| 2.2 Patient‐reported symptom scores—Bausch: LE + CsA |
6 |
462 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.35 [‐0.54, ‐0.17] |
| 2.3 Patient‐reported symptom scores—by regimen |
6 |
531 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.30 [‐0.48, ‐0.12] |
| 2.3.1 Steroid alone vs. CsA 0.05% |
3 |
172 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.13 [‐0.43, 0.17] |
| 2.3.2 Steroid run‐in before initiating CsA 0.05% |
2 |
178 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.21 [‐0.50, 0.09] |
| 2.3.3 Steroid run‐in with CsA 0.05% |
2 |
181 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.56 [‐0.86, ‐0.27] |
| 2.4 Patient‐reported symptom scores—steroid treatment duration |
6 |
530 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.26 [‐0.43, ‐0.08] |
| 2.4.1 High dose for 3‐4 weeks before tapering |
2 |
106 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.09 [‐0.47, 0.30] |
| 2.4.2 8 weeks |
4 |
355 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.37 [‐0.58, ‐0.16] |
| 2.4.3 12 weeks |
1 |
69 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.05 [‐0.42, 0.52] |
| 2.5 Tear film break‐up time—Bausch: LE alone |
5 |
353 |
Mean Difference (IV, Random, 95% CI) |
0.37 [‐0.13, 0.87] |
| 2.6 Tear film break‐up time—Bausch: LE + CsA |
5 |
350 |
Mean Difference (IV, Random, 95% CI) |
0.36 [‐0.15, 0.87] |
| 2.7 Tear film break‐up time—by regimen |
5 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 2.7.1 Steroid alone |
3 |
172 |
Mean Difference (IV, Random, 95% CI) |
0.28 [‐0.74, 1.30] |
| 2.7.2 Steroid + CsA |
3 |
247 |
Mean Difference (IV, Random, 95% CI) |
0.46 [0.16, 0.76] |
| 2.8 Tear film break‐up time—by steroid treatment duration |
5 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 2.8.1 High dose for 2‐4 weeks before tapering |
1 |
66 |
Mean Difference (IV, Random, 95% CI) |
0.09 [‐0.86, 1.04] |
| 2.8.2 Fixed dose for 8 weeks |
2 |
103 |
Mean Difference (IV, Random, 95% CI) |
0.32 [‐1.20, 1.84] |
| 2.8.3 Fixed dose for 3 months |
3 |
250 |
Mean Difference (IV, Random, 95% CI) |
0.47 [0.17, 0.77] |
| 2.9 Corneal fluorescein staining scores—Bausch: LE alone |
6 |
465 |
Std. Mean Difference (IV, Random, 95% CI) |
0.05 [‐0.25, 0.35] |
| 2.10 Corneal fluorescein staining score—Bausch: LE + CsA |
6 |
462 |
Std. Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.27, 0.29] |
| 2.11 Corneal fluorescein staining score—by grading system |
6 |
531 |
Std. Mean Difference (IV, Random, 95% CI) |
0.05 [‐0.20, 0.31] |
| 2.11.1 NEI grading system |
4 |
428 |
Std. Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.31, 0.32] |
| 2.11.2 Other grading system |
2 |
103 |
Std. Mean Difference (IV, Random, 95% CI) |
0.20 [‐0.22, 0.62] |
| 2.12 Corneal fluorescein staining score—by regimen |
6 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 2.12.1 Steroid alone vs. CsA 0.05% |
3 |
172 |
Std. Mean Difference (IV, Random, 95% CI) |
0.25 [‐0.06, 0.55] |
| 2.12.2 Steroid run‐in before intitiating CsA 0.05% |
2 |
178 |
Std. Mean Difference (IV, Random, 95% CI) |
0.16 [‐0.14, 0.45] |
| 2.12.3 Steroid run‐in concurrently with CsA 0.05% |
2 |
181 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.33 [‐0.73, 0.07] |
| 2.13 Corneal fluorescein staining score—by steroid treatment duration |
6 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 2.13.1 For 3‐4 weeks |
2 |
107 |
Std. Mean Difference (IV, Random, 95% CI) |
0.06 [‐0.32, 0.44] |
| 2.13.2 For 8 weeks |
4 |
355 |
Std. Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.39, 0.42] |
| 2.13.3 For 12 weeks |
1 |
69 |
Std. Mean Difference (IV, Random, 95% CI) |
0.32 [‐0.15, 0.80] |
| 2.14 Tear osmolarity |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 2.14.1 LE gel 0.5% alone |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 2.14.2 LE gel 0.5% plus CsA |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 2.15 Schirmer's test |
4 |
361 |
Mean Difference (IV, Random, 95% CI) |
1.19 [‐0.40, 2.77] |
| 2.15.1 Steroid alone |
1 |
68 |
Mean Difference (IV, Random, 95% CI) |
0.12 [‐0.59, 0.83] |
| 2.15.2 Combination |
3 |
293 |
Mean Difference (IV, Random, 95% CI) |
1.73 [0.32, 3.13] |
| 2.16 Schirmer's test—by steroid type |
4 |
361 |
Mean Difference (IV, Random, 95% CI) |
1.19 [‐0.40, 2.77] |
| 2.16.1 Ketone steroid: MP + CsA |
1 |
41 |
Mean Difference (IV, Random, 95% CI) |
0.80 [‐0.52, 2.12] |
| 2.16.2 Ester steroid: LE ± CsA |
3 |
320 |
Mean Difference (IV, Random, 95% CI) |
1.32 [‐0.72, 3.36] |
| 2.17 Proportion of participants with increased IOP |
4 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 2.18 Proportion of participants with any ocular complication |
3 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 2.18.1 Steroid alone |
2 |
103 |
Risk Ratio (M‐H, Random, 95% CI) |
0.61 [0.11, 3.43] |
| 2.18.2 Steroid plus CsA |
2 |
110 |
Risk Ratio (M‐H, Random, 95% CI) |
0.65 [0.11, 3.80] |
