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. 2022 Oct 5;13:907579. doi: 10.3389/fphar.2022.907579

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Copyright © 2022 Morash, Nixon, Shimoda, Turner, Stokes, Small-Howard and Ellis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of the larval zebrafish OHDA model. Panel (A) Behavioral profiles of total distance traveled (60 s bins) following OHDA exposure from 48 to 120 hpf. Panel (B) Total distance travelled during the first 90 min in the light following OHDA exposure from 48 to 120 hpf (n = 36). Advanced activity analytics (C,D) of Total Frequency of switching between activity states (C) and the nested Cumulative Duration in each activity state (D) (n = 48). CC vs. OHDA, ** = p < 0.01 **** = p < 0.0001.