Extended Data Fig. 6. Contribution of CpGs and PCs to PC clocks.

a, The effect of a 1 SD change in beta for each CpG on the PC clocks. This was calculated by multiplying the CpG loadings for each PC by the PC weight in the clock, summing these products for each CpG, and multiplying by CpG standard deviation from the GSE55763. Effects are shown on a log base 10 scale. Note that results were similar using standard deviations from the PC clock training data. CpGs present in the original clock are denoted in red. b, Effect of 1 SD change in PC score for each PC on the overall clock. c, Cumulative sum of 1 SD changes in PC scores for each PC (black), plotted against cumulative variance explained for each PC in the original training data (grey).