Table 2.
Summary of hierarchical regression models linking infant characteristics and prenatal adversity factors with neonatal mean diffusivity (MD) fractional anisotropy (FA) (n = 289)
| MD | FA | |||||||
|---|---|---|---|---|---|---|---|---|
| β (95% CI) | SE | q | Δ R2 | β (95% CI) | SE | q | Δ R2 | |
| R dorsal cingulum | R2 = 0.25* | … | R2 = 0.13* | … | ||||
| Sex | −0.02 (−0.12–0.08) | 0.05 | 0.87 | … | −0.11 (−0.22–−0.01) | 0.06 | 0.13 | … |
| PMA at scan | −0.50 (−0.61–−0.40) | 0.05 | <0.001 | … | 0.32 (0.21–0.43) | 0.06 | <0.001 | … |
| Social disadv. | −0.17 (−0.28–−0.06) | 0.06 | 0.008 | 0.03† | 0.18 (0.06–0.30) | 0.06 | 0.02 | 0.03‡ |
| Psych. stress | 0.02 (−0.09–0.12) | 0.06 | 0.94 | … | −0.07 (−0.19–0.05) | 0.06 | 0.57 | … |
| L dorsal cingulum | R2 = 0.22* | … | R2 = 0.13* | … | ||||
| Sex | −0.02 (−0.13–0.08) | 0.05 | 0.87 | … | −0.16 (−0.27–−0.05) | 0.06 | 0.03 | … |
| PMA at scan | −0.47 (−0.58–−0.37) | 0.05 | <0.001 | … | 0.30 (0.19–0.41) | 0.06 | <0.001 | … |
| Social disadv. | −0.10 (−0.22–0.01) | 0.06 | 0.07 | 0.02‡ | 0.14 (0.02–0.26) | 0.06 | 0.07 | 0.02 |
| Psych. stress | −0.06 (−0.17–0.05) | 0.06 | 0.94 | … | −0.03 (−0.14–0.09) | 0.06 | 0.83 | … |
| R inferior cingulum | R2 = 0.29* | … | R2 = 0.11* | … | ||||
| Sex | −0.10 (−0.20–0.01) | 0.05 | 0.16 | … | 0.06 (−0.05–0.17) | 0.06 | 38 | … |
| PMA at scan | −0.52 (−0.62–−0.41) | 0.05 | <0.001 | … | 0.34 (0.23–0.45) | 0.06 | <0.001 | … |
| Social disadv. | −0.25 (−0.36–−0.14) | 0.06 | <0.001 | 0.06* | 0.05 (−0.07–0.17) | 0.06 | 0.71 | <0.01 |
| Psych. stress | <0.01 (−0.10–0.11) | 0.06 | 0.94 | … | 0.02 (−0.10–0.14) | 0.06 | 0.83 | … |
| L inferior cingulum | R2 = 0.36* | … | R2 = 0.11* | … | ||||
| Sex | −0.11 (−0.20–−0.02) | 0.05 | 0.16 | … | −0.06 (−0.17–0.05) | 0.06 | 0.38 | … |
| PMA at scan | −0.59 (−0.68–−0.49) | 0.05 | <0.001 | … | 0.31 (0.19–0.42) | 0.06 | <0.001 | … |
| Social disadv. | −0.21 (−0.32–−0.11) | 0.05 | <0.001 | 0.06* | −0.01 (−0.13–0.12) | 0.06 | 0.97 | 0.01 |
| Psych. stress | −0.05 (−0.15–0.05) | 0.05 | 0.94 | … | 0.10 (−0.02–0.22) | 0.06 | 0.57 | … |
| R uncinate | R2 = 0.21* | … | R2 = 0.26* | … | ||||
| Sex | −0.06 (−0.16–0.05) | 0.05 | 0.69 | … | −0.11 (−0.21–−0.01) | 0.05 | 0.11 | … |
| PMA at scan | −0.46 (−0.57–−0.36) | 0.05 | <0.001 | … | 0.49 (0.39–0.59) | 0.05 | <0.001 | … |
| Social disadv. | −0.11 (−0.22–0.01) | 0.06 | 0.07 | 0.01 | <0.01 (−0.11–0.11) | 0.06 | 0.97 | <0.01 |
| Psych. stress | −0.01 (−0.13–0.10) | 0.06 | 0.94 | … | −0.01 (−0.12–0.10) | 0.06 | 0.84 | … |
| L uncinate | R2 = 0.16* | … | R2 = 0.19* | … | ||||
| Sex | −0.05 (−0.16–0.06) | 0.06 | 0.69 | … | <−0.01 (−0.11–0.10) | 0.05 | 0.94 | … |
| PMA at scan | −0.40 (−0.51–−0.29) | 0.06 | <0.001 | … | 0.43 (0.32–0.54) | 0.05 | <0.001 | … |
| Social disadv. | −0.17 (−0.29–−0.05) | 0.06 | 0.01 | 0.03† | 0.02 (−0.10–0.13) | 0.06 | 0.97 | 0.01 |
| Psych. stress | −0.01 (−0.12–0.11) | 0.06 | 0.94 | … | 0.08 (−0.03–0.20) | 0.06 | 0.57 | … |
| R fornix | R2 = 0.32* | … | R2 = 0.11* | … | ||||
| Sex | 0.01 (−0.09–0.11) | 0.05 | 0.87 | … | −0.08 (−0.20–0.03) | 0.06 | 0.22 | … |
| PMA at scan | −0.57 (−0.67–−0.47) | 0.05 | <0.001 | … | 0.31 (0.20–0.43) | 0.06 | <0.001 | … |
| Social disadv. | −0.14 (−0.25–−0.04) | 0.05 | 0.01 | 0.02‡ | 0.14 (0.02–0.26) | 0.06 | 0.07 | 0.02 |
| Psych. stress | 0.03 (−0.08–0.13) | 0.05 | 0.94 | … | −0.07 (−0.19–0.06) | 0.06 | 0.57 | … |
| L fornix | R2 = 0.31* | … | R2 = 0.10* | … | ||||
| Sex | 0.01 (−0.09–0.11) | 0.05 | 0.87 | … | −0.10 (−0.21–0.01) | 0.06 | 0.18 | … |
| PMA at scan | −0.56 (−0.66–−0.47) | 0.05 | <0.001 | … | 0.28 (0.16–0.39) | 0.06 | <0.001 | … |
| Social disadv. | −0.10 (−0.20–0.01) | 0.05 | 0.07 | 0.01 | 0.11 (−0.02–0.23) | 0.06 | 0.17 | 0.02 |
| Psych. stress | 0.01 (−0.09–0.12) | 0.05 | 0.94 | … | 0.04 (−0.08–0.16) | 0.06 | 0.83 | … |
q, significance value adjusted for multiple comparisons using Benjamini–Hochberg false discovery rate procedure (bold values indicate significant results (q < 0.05) after correction); Δ, change; R, right; L, left; PMA, postmenstrual age; disadv., Disadvantage; psych., Psychosocial.
*Model significance: P < 0.001.
†Model significance: P < 0.01.
‡Model significance: P < 0.05.