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Inhibition of CaMKII depresses synaptic transmission. Slice cultures are bathed in APV and nifedipine to prevent Ca2+ entry into the cells. (A) Bath application of the membrane permeable CaMKII inhibitor myr-CN27 depresses synaptic transmission (n = 7). (B) Diagram of light-inducible CaMKII inhibitor (paAIP2) [reproduced from (24)]. (C) Exposure of cells transfected with paAIP2 to blue light depresses synaptic transmission (n = 11).
