Fig. 2.

ADAM17 promotes pancreatic immune cell infiltration, inflammation and acinar cell death in the cerulein-induced AP model. (A, C, and F) Representative images of CD45, CD3, and TUNEL-stained pancreatic sections from WT mice and Adam17^ex/ex mice (ex/ex) treated with either PBS or cerulein (Cer), respectively. (Scale bars, 100 μm) (B, D, and G) Quantification of CD45, CD3, and TUNEL-positive cells per high-power field (HPF) in pancreatic tissues of the indicated groups, respectively (n = 6 to 8 per group). (E) qPCR expression analysis of inflammatory genes (normalized against 18s rRNA) in pancreatic tissues from the indicated mice (n = 5 to 7 per group). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; ns, not significant, one-way ANOVA.