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. 2022 Oct 10;119(42):e2213744119. doi: 10.1073/pnas.2213744119

Fig. 8.

Fig. 8.

Up-regulation of ADAM17/sIL-6R/pSTAT3 in human pancreatitis. (A) Representative images of ADAM17-stained pancreatic sections from non-cancerous normal and pancreatitis biopsies. (Scale bar, 100 μm) (B) Quantification of ADAM17 staining intensity in pancreatic tissues of the indicated groups (n = 3 to 4 per group). (C) Serum levels of soluble IL-6R (sIL-6R; ng/mL) in the indicated groups (n = 11 per group). (D) Representative images of pTyr705 STAT3-stained pancreatic sections from non-cancerous normal and pancreatitis biopsies. (Scale bar, 100 μm) (E) Quantification of pTyr705 STAT3 staining intensity in pancreatic tissues of the indicated groups (n = 3 to 4 per group). *P < 0.05, **P < 0.01, Student’s t test. (F) Linear regression analysis of ADAM17 with pTyr705 STAT3 staining in pancreatic sections from non-cancerous normal and pancreatitis biopsies. r, Pearson correlation coefficient.