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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2022 Jun 9;188:146–161. doi: 10.1016/j.freeradbiomed.2022.06.004

Figure 1.

Figure 1.

Beneficial effects of GPx1. By attenuating the accumulation of cellular reactive oxygen species, GPx1 protects against dysfunction and disease in many biological systems. Arrows indicate that GPx1 expression is associated with these changes and that GPx1 deficiency attenuates these protective effects. Overexpression of GPx1 or use of ebselen, a GPx1 mimetic, has been shown to augment many of these protective effects of GPx1. Regarding metabolism, both the loss and the overexpression of GPx1 may promote metabolic dysfunction. Other examples where increased expression of GPx1 may alter normal function are discussed further in the text. I/R, ischemia/reperfusion; NO, nitric oxide; EPC, endothelial progenitor cells.