Table 3. Crude and adjusted Hazard Ratios for differentiated thyroid cancer patients, using the Cox model.

Variables		Crude HR^a	95%CI^b	p value^c	Multivariate model using age grouping of the TNM 7^th edition			Multivariate model using age grouping of the TNM 8^th edition
Variables		Crude HR^a	95%CI^b	p value^c	adjusted HR^a	95%CI^b	p value^c	adjusted HR^a	95%CI^b	p value^c
Gender
	Female	1.00			Multivariate Cox model stratified by gender
	Male	2.75	1.16 – 6.52	0.022	Multivariate Cox model stratified by gender
Age at diagnosis – TNM 7^th edition
	20-44	1.00			1.00			-	-	-
	≥ 45	8.68	2.02 – 37.27	0.004	9.88	1.67 – 58.33	0.011	-	-	-
Age at diagnosis – TNM 8^th edition
	20-54	1.00			-	-	-	1.00
	≥ 55	17.60	5.18 – 59.76	< 0.001	-	-	-	10.12	2.05 – 50.09	0.005
Distant metastasis
	No	1.00			1.00			1.00
	Yes	28.61	12.08 – 67.77	< 0.001	18.87	7.38 – 48.29	< 0.001	12.43	4.58 – 33.77	< 0.001
Radioiodine therapy
	No	1.00			1.00			1.00
	Yes	0.22	0.09 – 0.52	0.001	0.16	0.06 – 0.43	< 0.001	0.19	0.07 – 0.51	0.001
Lymphadenectomy
	No	1.00			1.00			1.00
	Yes	2.57	1.10 – 6.02	0.035	6.36	2.26 – 17.91	0.001	5.06	1.82 – 14.05	0.002
Tumor size
	< 4.0 cm	1.00			-	-	-	-	-	-
	≥ 4.0 cm	5.18	2.20 – 12.2	< 0.001	-	-	-	-	-	-
Microcarcinoma
	Yes	1.00			-	-	-	-	-	-
	No	2.71	0.80 – 9.20	0.110	-	-	-	-	-	-
Radiotherapy
	No	1.00
	Yes	8.96	3.47 – 23.13	< 0.001

Hazard Ratio;

CI= confidence interval;

Wald’s test p value, being in bold when p < 0.05.

Histological type and regional lymph nodes metastasis variables presented p > 0.20 in univariate Cox model.