Table 3. Topics covered in internal horizon scanning reports and purposes.

Topic	Purpose
Beta idursulfase for mucopolysaccharidosis type 2 (Hunter syndrome)	Judicial defense
Mipomersen for homozygous familial hypercholesterolaemia
Eculizumab for paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome
Metreleptin for Berardinelli-Seip syndrome
Pompe disease	Elaboration of PCDT
Fabry’s disease
Mucopolysaccharidoses type 1 and 2
Medicines for familial amyloidotic polyneuropathy associated with transthyretin
Watson robot	To inform MH managers
Rapid diagnostic method of bacterial meningitis
Diagnostic method of colorectal cancer by stool DNA
Medicines for chronic hepatitis C
Severe asthma medications
Recombinant factors VIII for Haemophilia A	Research and Development (R&D)
Medicines for Amyotrophic Lateral Sclerosis	Preparation for patients and MH managers meeting

PCDT: Brazilian clinical guidelines; MH: Ministry of Health