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. 2022 Oct 21;8(42):eadd3914. doi: 10.1126/sciadv.add3914

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Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 5. — (A) Side-view cartoon depiction of the AP-1:Arf1₂:Nef asymmetric unit from the narrow tube lattice with inset showing the Nef:MHC-I:μ1 interfaces. (B) A 180° rotated view of the inset shown in (A). (C) Top-view cartoon depiction of the AP-1:Arf1:Nef lattice with inset showing the Nef:μ1:MHC-I:Arf1^β1 quaternary complex (map threshold, 3.5 SD). The red asterisk denotes the μ1 internal loop stabilized by Nef. (D) Inset showing the Nef ExxxLL:σ1 interface. The map density is fit with a hypothetical structural model based on the predicted and solved structures. The ExxxLL motif of Nef observed in the AP-1:Arf1:BST2-Nef closed trimer (PDB: 6CM9) is shown in black for comparison. (E) A 90° rotated view of (D). The map threshold density was set to 3.5 SD from the mean. The ExxxLL motif of Nef from PDB: 6cm9 (black) is modeled as in (D).