Table 2.
Description of the genetic variants used as instrumental variables in the MR analysis for each dataset
| Exposure | Data source | Number of IVs | F-statistica | Overall R2 |
|---|---|---|---|---|
| CRP | Ligthart et al.41 | 31 | 49 (25; 2070.3) | 5.3% |
| CCGC42 | 1 | 311.2 | 0.7% | |
| IL-6 | Ahluwalia et al.43 | 2 | 37.8; 397.7 | 0.4% |
| IL6R consortium45 | 1 | 63.1 | 0.4% | |
| Folkersen et al.44 (SCALLOP) | 2 | 35.6; 198.5 | 1.7% | |
| IL-1ra | Herder et al.46 | 1 | 169 | 0.2% |
| Folkersen et al.44 (SCALLOP) | 5 | 170.2 (30.0; 384.8) | 4.9% | |
| TNF-α | Prins21 | 3 | 30.9 (28.4; 39.5) | 0.2% |
Information on the exposure, the dataset source, the number of instrumental variables (IVs), the strength of the SNP-exposure association (using F-statistic) and the overall proportion of exposure variance explained by the IVs (R2). CCGC = CRPC-reactive protein coronary heart disease genetics collaboration; SCALLOP = systematic and combined analysis of Olink proteins.
a
When only one IV was available, a single value is reported. For two instruments, both F-statistic values are shown. For >2 instruments, median (range) are reported.